Chemistry And Application Of Click Chemistry - 1411 Words

Click Chemistry and Application Zhuo Wang Abstract: Discuss the history, mechanism and application of â€Å"Click chemistry†. Through the introduction of â€Å"Click chemistry†, demonstrate the role it plays in chemical biology filed, the typical synthesis way of this concept, and current application in drug synthesis and research. Keywords: Click chemistry, vivo system, Huisgen 1,3-dipolar cycloaddition, CuAAC, Diels-Alder reaction Introduction: The phrase click chemistry was invented by K. Barry Sharpless in 1998, and was first integrally described by Sharpless, Hartmuth Kolb, and M.G. Finn of The Scripps Research Institute in 2001.[1][2] In Chemical synthesis, â€Å"Click Chemistry† is a category bio-compatible reactions which have potential to be the special synthesis way of specific bio-molecules. It is not an isolated specific synthesis reaction, but include a sort of relevant products, which also engenders big molecule by linking small specific molecules together. Usually click reactions link a bio-molecule and a target molecule. Click chemistry is not limited to biological field, the idea of a click reaction has been applied in pharmacological and various bio-mimetic applications. However, they have been made significantly appliance in the detection, localization and qualification of bio-molecules. Click reactions are one-pot reactions, which are not hindered by water, generate mineral salt and inoffensive byproducts, and are characterized by a high thermodynamic drivingShow MoreRelatedDiscussion for Gas Law Experiment1537 Words   |  7 PagesChemistry 1061: Principles of Chemistry I Gas Laws Gas Laws: Pressure, Volume, and Temperature Introduction Pressure, volume, and temperature are properties of gases that reveal their relationships when any one of them is varied. Changing the temperature of a gas may change its volume or pressure, but how? What are the mathematical relationships between these properties? Are there limits to them? 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